Drug eruption - Echdoriad Cyffuriau
☆ Yng nghanlyniadau Stiftung Warentest 2022 o’r Almaen, roedd boddhad defnyddwyr â ModelDerm ond ychydig yn is nag ymgynghoriadau telefeddygaeth taledig.
Mae Echdoriad Cyffuriau (Drug eruption) yn cael ei nodweddu gan effeithio ar y corff cyfan.
References
Gall adweithiau croen a achosir gan feddyginiaeth, a elwir yn ffrwydradau cyffuriau, fod yn ddifrifol weithiau. Mae'r adweithiau difrifol hyn, a elwir yn severe cutaneous adverse drug reactions (SCARs) , yn cael eu hystyried yn rhai sy'n bygwth bywyd. Maent yn cynnwys amodau fel Stevens-Johnson syndrome (SJS) , toxic epidermal necrolysis (TEN) , acute generalized exanthematous pustulosis (AGEP) , and drug reaction with eosinophilia and systemic symptoms (DRESS) . Er bod SCARs yn brin, mae tua 2% o gleifion mewn ysbytai yn eu profi.
Adverse drug reactions involving the skin are commonly known as drug eruptions. Severe drug eruption may cause severe cutaneous adverse drug reactions (SCARs), which are considered to be fatal and life-threatening, including Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), acute generalized exanthematous pustulosis (AGEP), and drug reaction with eosinophilia and systemic symptoms (DRESS). Although cases are relatively rare, approximately 2% of hospitalized patients are affected by SCARs.
Adverse drug reactions involving the skin are commonly known as drug eruptions. Severe drug eruption may cause severe cutaneous adverse drug reactions (SCARs), which are considered to be fatal and life-threatening, including Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), acute generalized exanthematous pustulosis (AGEP), and drug reaction with eosinophilia and systemic symptoms (DRESS). Although cases are relatively rare, approximately 2% of hospitalized patients are affected by SCARs.
Ymwelodd dynes 31 oed â'r adran ddermatoleg gyda darn coch di-boen ar ben ei throed dde. Cymerodd un dos o doxycycline (100 mg) y diwrnod cynt, yn dilyn triniaeth laser picosecond ar gyfer creithiau acne. Y llynedd, cafodd broblem debyg yn yr un fan ar ôl cymryd yr un dos o driniaeth ôl-laser doxycycline. Nid oes ganddi unrhyw hanes meddygol arwyddocaol nac unrhyw symptomau eraill, fel twymyn, yn lleol na thrwy gydol ei chorff.
A 31-year-old woman presented to the dermatology department with an asymptomatic erythematous patch on the dorsum of her right foot. She had taken 1 dose of doxycycline (100 mg) the previous day as empirical treatment after picosecond laser treatment for acne scars. She had had a similar episode the previous year on the same site, after taking the same dose of doxycycline after laser treatment. She had no notable medical history, and no other local or systemic symptoms, including fever.
A 31-year-old woman presented to the dermatology department with an asymptomatic erythematous patch on the dorsum of her right foot. She had taken 1 dose of doxycycline (100 mg) the previous day as empirical treatment after picosecond laser treatment for acne scars. She had had a similar episode the previous year on the same site, after taking the same dose of doxycycline after laser treatment. She had no notable medical history, and no other local or systemic symptoms, including fever.
Mae Stevens-Johnson syndrome (SJS) a toxic epidermal necrolysis (TEN) yn ddau fath o adwaith croen difrifol, sy'n wahanol i gyflyrau croen eraill fel erythema multiforme mawr a syndrom croen sgaldio staphylococcal, yn ogystal ag adweithiau cyffuriau. Mae SJS/TEN yn adwaith prin a difrifol sy'n achosi niwed eang i'r croen a'r bilen mwcaidd, yn aml gyda symptomau systemig. Mewn dros 80% o achosion, meddyginiaethau yw'r achos.
Stevens-Johnson syndrome (SJS), and toxic epidermal necrolysis (TEN) are variants of the same condition and are distinct from erythema multiforme major staphylococcal scalded skin syndrome, and other drug eruptions. Stevens-Johnson syndrome/toxic epidermal necrolysis is a rare, acute, serious, and potentially fatal skin reaction in which there are sheet-like skin and mucosal loss accompanied by systemic symptoms. Medications are causative in over 80% of cases.
Stevens-Johnson syndrome (SJS), and toxic epidermal necrolysis (TEN) are variants of the same condition and are distinct from erythema multiforme major staphylococcal scalded skin syndrome, and other drug eruptions. Stevens-Johnson syndrome/toxic epidermal necrolysis is a rare, acute, serious, and potentially fatal skin reaction in which there are sheet-like skin and mucosal loss accompanied by systemic symptoms. Medications are causative in over 80% of cases.
Gwneir diagnosis o ffrwydradau cyffuriau yn bennaf o'r hanes meddygol a'r archwiliad clinigol. Gall biopsi croen, profion gwaed neu brofion imiwnolegol fod yn ddefnyddiol hefyd.
Enghreifftiau o gyffuriau cyffredin sy'n achosi'r ffrwydrad yw gwrthfiotigau a chyffuriau gwrthficrobaidd eraill, cyffuriau sulfa, cyffuriau gwrthlidiol ansteroidal (NSAIDs), asiantau cemotherapi ar gyfer malaeneddau, cyffuriau gwrthgonfylsiwn a chyffuriau seicotropig.
○ Diagnosis a Thriniaeth
Os oes gennych dwymyn (cynnydd yn nhymheredd y corff), dylech ofyn am sylw meddygol cyn gynted â phosibl. Dylid rhoi’r gorau i’r cyffur a amheuir (e.e. gwrthfiotigau, cyffuriau gwrthlidiol ansteroidal). Cyn ymweld â'r ysbyty, gall gwrth-histaminau geneuol fel cetirizine neu loratadine helpu ar gyfer cosi a brech.
#Cetirizine [Zytec]
#LevoCetirizine [Xyzal]
#Loratadine [Claritin]
Prawf gwaed (CBC, LFT, cyfrif eosinoffilia)
Steroidau geneuol a gwrth-histaminau gyda phresgripsiwn meddyg